Cisplatin hepatotoxicity
WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of …
Cisplatin hepatotoxicity
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WebDec 1, 2024 · 1.2. Toxicity of cisplatin. Cisplatin can be considered a double-edged sword. It is a potent anticancer agent, at the same time has toxic effect on various tissues as it … WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver …
WebTo date, no published guidelines exist for managing a cisplatin overdose. The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, … WebFeb 1, 2024 · Hesperidin plays an important role in the prevention of many diseases due to its anti-inflammatory, anti-oxidant, anti-ulcer, and anti-carcinogenic activities,2,3in addition to its anti-melanogenic and neuroprotective effects.4,5Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects.6-8The …
WebJan 14, 2024 · This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying … Webabstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells.
WebHepatotoxicity was induced in animals by an intraperitoneal injec-tion of acetaminophen (750 mg/kg body weight) in a freshly prepared physi-ological saline solution kept in warm boiling water bath and used after cooling at 370C, as a single dose on the first day. The rats were randomly divided into five groups of six animals each as given below.
WebApr 1, 1993 · To report a case of possible cisplatin-associated hepatotoxicity. CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m 2 ) and … dd wrt to openwrt flashWebNational Center for Biotechnology Information dd wrt tomato firmwareWebCisplatin (cis-diamminedichloroplatinium, CDDP), one of the most widely used chemotherapeutic drugs for a variety of tumors, exhibits anticancer activity via formation of CDDP-DNA adducts. 6 However, its clinical use has been hampered by the intrinsic and adaptive resistances of the tumor cells along with severe toxic effects, which greatly … dd-wrt tomato openwrtWebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, … gemini tomorrow loveWebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … gemini tool waterbury ctWebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. … gemini tomorrow love horoscopeWebFeb 2, 2024 · There is substantial evidence that protective medications can alleviate drug-induced organ toxicity by modulating both Nrf2 and NF-κB signaling pathways. Thus, it has become increasingly important to explore the crosstalk mechanism between Nrf2 and NF-κB in drug-induced toxicity. ddwrt toolchain gui ide