Clec12a marker
WebNational Center for Biotechnology Information WebMar 1, 2024 · The CLEC12A gene is located on chromosome 12p13 in a region near a cluster of C-type lectins/NK gene complex [19,20] and encodes 6 exons [21,22. …
Clec12a marker
Did you know?
WebMar 16, 2024 · CLEC12A and ACHE showed improved prediction of patient outcomes compared to standard clinical biomarkers including CRP and PCT in combination … WebCLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout …
WebCLEC12A high was positively associated with immune checkpoint genes as well as macrophage associated genes. CLEC12A is an ideal chimeric antigen receptor T-cell … WebMar 17, 2016 · Abstract. The C-type lectin domain family 12 member A (Clec12A/MICL) is an inhibitory receptor encoded in the Dectin-1 cluster. It is widely expressed in myeloid …
CLEC12A, also known as MICL, is inhibitory C-type lectin-like receptor. It contains ITIM motif in cytoplasmic tail that can associate with signaling phosphatases SHP-1 and SHP-2. There are two types, human (hMICL) and murine (mMICL). See more C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) … See more In the immunotherapy of acute myeloid leukemia (AML), CLL-1 becomes one of the target due to its high expression in AML cells while … See more • Human CLEC12A genome location and CLEC12A gene details page in the UCSC Genome Browser. See more • Drickamer K (October 1999). "C-type lectin-like domains". Current Opinion in Structural Biology. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3 See more WebEarlier studies identified the transmembrane cell surface C-type lectin CLEC14A as a putative tumour endothelial marker. For CLEC14A to progress as a vascular target in solid tumours an in-depth analysis of CLEC14A expression in human healthy and tumour tissue is …
WebCLEC12A receptor has emerged as a leukemia-associated and cancer stem cell marker in myeloid malignancies (10). CLEC12A is a myeloid lineage antigen that is highly expressed by AML cells and LSCs, but not expressed by normal hematopoietic stem cells (HSCs).
WebCLEC12A (also known as myeloid inhibitory C-type lectin-like receptor, MICL) is an ITIM-containing inhibitory CLR, which are expressed by granulocytes, monocytes, macrophages and DCs [47,48]. This membrane-bound receptor is a homodimer and has been considered to be a marker for AML blasts. cheap bus tickets from binghamton to nycWebDec 2, 2016 · We also show that CLEC12A is overexpressed on bone marrows from patients with AML that fail to achieve a complete remission after induction chemotherapy, suggesting that it could be a marker for residual disease that is refractory to chemotherapy. We then separated AML blasts into CLEC12A positive or negative cells by magnetic … cute things to make for your bfWebAug 26, 2024 · Clec12A (also known as MICL, CLL-1, or DCAL-2) is a prototypic ITIM-containing CLR that is predominantly expressed on myeloid cells (9, 10).Earlier studies have demonstrated that Clec12A couples to SHP-1 and SHP-2 after SFK-mediated ITIM phosphorylation ().Moreover, recent work identified Clec12A as a specific receptor for … cheap bus tickets from nyc to atlantic cityWebMar 16, 2024 · CLEC12A belongs to the dectin gene cluster and is a transmembrane cell surface receptor expressed mainly on myeloid cells that binds monosodium urate (MSU) crystals. MSU crystals are DAMPs formed... cute things to put in your carWebFeb 7, 2024 · 1 INTRODUCTION. The transmembrane receptor C-type lectin domain family 12, member A (CLEC12A) is emerging as a marker of blasts and leukaemic stem cells … cute things to put on your bioWebThe 50C1 monoclonal antibody specifically binds to human CD371 which is also known as Clec12A (C-type lectin domain family 12 member A), C-type lectin-like molecule 1 (CLL-1), myeloid inhibitory C-type lectin-like receptor (MICL), or dendritic cell-associated lectin 2 (DCAL-2). It is expressed on a variety of cells including monocytes, macrophages, … cheap bus tickets from cleveland to new yorkWebJan 9, 2024 · CLEC12A is a promising target for AML as it is aberrantly expressed in about 90% of AML patients and is a stable and reliable marker of leukemic stem cells. In contrast, CLEC12A expression is low or absent on normal hematopoietic stem cells. Several therapies targeting CLEC12A are in or are about to begin clinical development. cheap bus tickets from manchester to london