This program aims to develop anti-HHLA2 therapeutic monoclonal antibody for immuno-oncology. HHLA2 inhibits TCR-mediated proliferation and cytokine production by CD4+ and CD8+ T cells. Studies have shown that HHLA2 expression is associated with EGFR mutation status and high tumor … See more HHLA2 is abbreviated for HERV-HLTR related 2 and is a newly identified immune checkpoint belonging to the B7 family. HHLA2 has been … See more HHLA2 is expressed in triple-negative breast cancer (TNBC) and melanoma but has a limited expression in normal tissues. Furthermore, the … See more Here are some published data about HHLA2 work as a potential target for cancer immunotherapy. 1. High HHLA2 expression was … See more To our knowledge, there are NOongoing clinical trials of anti-HHLA2 therapeutic monoclonal antibody. Our program will be a pioneer in the development of HHLA2 antibody. See more WebAug 29, 2012 · Sign up. See new Tweets
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